Registration Dossier
Registration Dossier
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EC number: 215-687-4 | CAS number: 1344-09-8
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- other: Expert judgement
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Product brochure of producers association; data without proof.
- Principles of method if other than guideline:
- Expert judgement based on structural considerations.
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented publications giving sufficient detail for evaluation.
- Principles of method if other than guideline:
- Feeding studies with rats, dogs, cats and guinea pigs. Measurement of urinary excretion by silica analysis of urine samples.
- GLP compliance:
- no
- Test organisms (species):
- other: rats, dogs, cats and guinea pigs
- Route of exposure:
- feed
- Remarks on result:
- not measured/tested
- Remarks:
- See "Any other information on results incl. tables"
Referenceopen allclose all
RM-Freetext:
Soluble silicates have no bioaccumulation potential. There are no structural alerts to suspect such a hazard.
Ingested silicates are excreted via urine and to a lesser extent via the faeces. Markedly increased and rapid urinary excretion of
silicawas observed when soluble sodium silicates were administered to rats (Benke & Osborn, 1979), dogs (King et al., 1933),
cats (King & McGeorge, 1938) and guinea pigs (Sauer et al., 1959). The urinary silicon excretion half-life after administration of
sodium silicate to rats via stomach tube was 24 h (Benke & Osborn, 1979).
Based on these metabolic considerations no bioaccumulation is to be expected.
Description of key information
Low potential for bioaccumulation.
Key value for chemical safety assessment
Additional information
Toxicokinetic data on vertebrates revealed a low potential for bioaccumulation. Ingested soluble silicates are excreted via urine and to a lesser extent via the faeces. Markedly increased and rapid urinary excretion of silica was observed when soluble sodium silicates were administered to rats (Benke & Osborn 1979), dogs (King et al. 1933), cats (King & McGeorge 1938) and guinea pigs (Sauer et al. 1959). The urinary silicon excretion half-life after administration of sodium silicate to rats via stomach tube was 24 h (Benke & Osborn 1979).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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