Registration Dossier

Toxicological information

Genetic toxicity: in vivo

Currently viewing:

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: We do not have the complete test report but only an extract given in the OECD SIDS report : Benzene C10-16 alkyl derivatives

Data source

Reference
Reference Type:
secondary source
Title:
The genetoxic potential of linear alkylbenzene mixtures in a short-term test battery
Author:
Robinson E.C. - Nair R.S.
Year:
1992
Bibliographic source:
Fund.Appl. Toxicol 18, 540-548,
Report Date:
2002

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 475 (Mammalian Bone Marrow Chromosome Aberration Test)
Principles of method if other than guideline:
Method EPA/TSCA bone marrow chromosome abberation
GLP compliance:
yes
Type of assay:
chromosome aberration assay

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Alkylate is a linear alkyl benzene with an alkyl substituent including < 1% C9, 7% C10, 25% C11, 48 % C12, 19% C13, 1% C14

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
no data
Details on exposure:
no data
Positive control(s):
no data

Examinations

Details of tissue and slide preparation:
no data

Results and discussion

Test results
Sex:
not specified
Genotoxicity:
negative
Toxicity:
yes
Remarks:
lowest producing toxicity : 127000 mg/kg
Additional information on results:
Effect on Mitotic index or P/N Ratio : no effect

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative