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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1988
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report Date:
1988

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
yes
Test type:
fixed dose procedure
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): 07651 B8 008
- Molecular formula (if other than submission substance): C18H30
- Molecular weight (if other than submission substance): 246 g
- Physical state: colorless liquid
- Lot/batch No.: O.E. 241
- Stability under test conditions: stable

Test animals

Species:
rat
Strain:
ICR
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: Hazleton Les Oncins
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: 5-7 weeks
- Housing: polycarbonate cages 305*180*184 mm
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: one week

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+-3ºC
- Humidity (%): 30-70% RH
- Air changes (per hr): not specified
- Photoperiod (hrs dark / hrs light): 7:30-19:30

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 h
Doses:
2004 mg/kg (2.33 ml/kg)
No. of animals per sex per dose:
preliminary study: 4 males/ 4 females
full study: 10 males / 10 females

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD0
Effect level:
> 2 004 mg/kg bw
Based on:
test mat.
Mortality:
no
Clinical signs:
no
Body weight:
no variation
Gross pathology:
not observed effects

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In this study a LD0 >=2004 mg/kg bw was observed (no mortalities)