Registration Dossier
Registration Dossier
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EC number: 203-079-1 | CAS number: 103-09-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The methodology used results in a LD50 value which is an extremly rough approximation
Data source
Reference
- Reference Type:
- publication
- Title:
- The place of the range finding test in the industrial toxicology laboratory.
- Author:
- Smyth Jr HF, Carpenter CP
- Year:
- 1 944
- Bibliographic source:
- J. Ind Hyg. Tocicol. 26, 269-273.
Materials and methods
- Principles of method if other than guideline:
- Range finding study for the assessment of the acute dermal toxicity of the test substance (generally, a consecutive treatment strategy was applied)
- GLP compliance:
- no
- Test type:
- other: range finding study with a consecutive treatment strategy
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylhexyl acetate
- EC Number:
- 203-079-1
- EC Name:
- 2-ethylhexyl acetate
- Cas Number:
- 103-09-3
- Molecular formula:
- C10H20O2
- IUPAC Name:
- 2-ethylhexyl acetate
- Details on test material:
- 2-ethylhexyl acetate, purity not specified
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- 4 days
- Doses:
- no data (dosages with a spacing factor of 10)
- No. of animals per sex per dose:
- 6 animals of unknown sex per dose
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 17 400 mg/kg bw
- Remarks on result:
- other: original value: 20 mL/kg, calculated with a density of 0.87 g/mL
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
