Registration Dossier
Registration Dossier
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EC number: 203-398-6 | CAS number: 106-44-5
Neurotoxicity
Administrative data
Description of key information
In an abstract only the examination of probable neurotoxicity of p-cresol was reported:
male and female CD rats received conrn oil solutions with 0, 50. 175, 600 mg/kg bw/day p-cresol by gavage once daily for 13 weeks. Dose-related signs of toxicity and in the high dosed rats neurobehavioral signs of toxicity were reported. The NOAEL is 50 mg/kg bw/day (abstract only, TRL 1986).
Key value for chemical safety assessment
Additional information
To examine probable neurotoxicity of p-cresol male and female CD rats received corn oil solutions with 0, 50. 175, 600 mg/kg bw/day p-cresol by gvage once daily for 13 weeks. Dose-related signs of toxicity and in the high dosed rats neurobehavioral signs of toxicity were reported. The NOAEL is 50 mg/kg bw/day (abstract only, TRL 1986)
Justification for classification or non-classification
no classification is required
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