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Short-term toxicity to aquatic invertebrates

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Description of key information

No effects of 2-ethylhexyl oleate to Daphnia magna were observed in the range of water solubility.

Key value for chemical safety assessment

Additional information

In general, all EC/EL50(48 h) values derived with different invertebrate species for various test substances in the SCAE C2 -C8 category were above the limit of water solubility, so that no toxicity of dissolved substance was found (chemical toxicity). There were, however, several descriptions of indirect toxicity by presumably physical effects of the test substance at concentrations between 1 and 100 mg/L.

The key study investigated the effects of 2-ethylhexyl oleate to the freshwater invertebrate Daphnia magna (Kuech and Wierich 1995). The study was performed according to the EU-method C.2 considering the VCI concept draft for the acute testing of poorly soluble substances from 1994-01-31 for 48 h. The first approach without removal of the insoluble particles resulted in immobilization rates between 0 and 100% (mean: 25%). After removal of insoluble particles (filtration) no effects to Daphnia magna were observed. Thus, it can be stated that the insoluble particles of the test substance resulted in negative physical effects to the test species (e.g. agglutination of gills). No effects in the range of water solubility were observed. This resulted in an EC50 (48h) > 100 mg/L (nominal).

A supporting study on the marine species Acartia tonsa as category read-across from Fatty acids, C16-18 and C18-unsatd., 2-ethylhexyl esters (CAS 85049-37-2), tested as WAF, reported an EL50(48h) > 2047 (1646 -2470) mg/L (Hudson 2000).

Thus, based on the above mentioned result, and due to the structural and profile similarities of the substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no toxicological effects on aquatic invertebrates are expected up to the limit of water solubility for 2 -ethylhexyl oleate (CAS 26399 -02 -0).