Registration Dossier

Ecotoxicological information

Long-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
fish life cycle toxicity
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:

Description of key information

No test data are available on the long-term toxicity of biphenyl-4,4'-diol to fish.

Key value for chemical safety assessment

Additional information

This data point has been waived on scientific grounds.

Based on the use patterns of biphenyl-4,4'-diol, significant exposure of the aquatic compartment is not expected to occur. Moreover, biphenyl-4,4'-diol has been shown to be amenable to rapid and complete ultimate biodegradation and is therefore non-persistent in the aquatic environment. Biphenyl-4,4'-diol is more acutely toxic to aquatic invertebrates than fish by nearly an order of magnitude. This is supported by the QSAR Toolbox prediction of the NOEC fish, based on the category approach and trend analysis (OECD QSAR Toolbox v 3.1, 2013). This predicted long-term endpoint for fish is higher than the experimentally-determined long-term NOEC obtained for Daphnia. The Daphnia reproduction test included in this dossier provides the representative endpoint that drives the aquatic risk assessment. Therefore, long-term toxicity studies with fish are not required and the further expenditure of vertebrate test organisms is not ethically justified.