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EC number: 202-200-5 | CAS number: 92-88-6
No test data are available on the long-term toxicity of biphenyl-4,4'-diol to fish.
This data point has been waived on scientific grounds.
Based on the use patterns of biphenyl-4,4'-diol, significant exposure of the aquatic compartment is not expected to occur. Moreover, biphenyl-4,4'-diol has been shown to be amenable to rapid and complete ultimate biodegradation and is therefore non-persistent in the aquatic environment. Biphenyl-4,4'-diol is more acutely toxic to aquatic invertebrates than fish by nearly an order of magnitude. This is supported by the QSAR Toolbox prediction of the NOEC fish, based on the category approach and trend analysis (OECD QSAR Toolbox v 3.1, 2013). This predicted long-term endpoint for fish is higher than the experimentally-determined long-term NOEC obtained for Daphnia. The Daphnia reproduction test included in this dossier provides the representative endpoint that drives the aquatic risk assessment. Therefore, long-term toxicity studies with fish are not required and the further expenditure of vertebrate test organisms is not ethically justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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