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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
June 1977 - May 1977
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Conducted prior to GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report Date:
1977

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Principles of method if other than guideline:
The method employed in the testing, evaluation and the scoring of the results was similar to that described in Section 1500.41 - Hazardous Substances and Articles, Administration and Enforcement Regulations, Federal Register vol. 38, No. 187, P. 27019, 27 September 1973.
GLP compliance:
no
Remarks:
Prior to GLP.

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
Substance: Zinc Salt of 2-mercaptotolylimidazole.

Sample received: May 3, 1977.

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
0.5g
Duration of treatment / exposure:
24 hours.
Observation period:
72 hours.
Number of animals:
Six.
Details on study design:
The test material was used as supplied. A group of six albino rabbits were clipped over a wide area. One side of the rabbits back was allowed to remain intact. A 0.5 g portion of material was applied to the intact skin site. Gauze patches were then placed over the treated area and an impervious material was wrapped snugly around the trunks of the animals to hold the patch in place.

The wrapping was removed at the end of the 24 hour period and the treated areas were examined. Reading were also made after 72 hours.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
other: all animals
Time point:
other: 24 h
Score:
0
Max. score:
0
Irritation parameter:
erythema score
Basis:
other: all animals
Time point:
other: 72 h
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
other: all animals
Time point:
other: 24 h
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
other: all animals
Time point:
other: 72 h
Score:
0
Max. score:
0
Other effects:
No effects.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
0/6 animals showed evidence of skin irritation in the study, therefore, ZMB2 is not classified as an irritant.