Registration Dossier
Registration Dossier
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EC number: 200-817-4 | CAS number: 74-87-3
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian cell study: DNA damage and/or repair
- Remarks:
- Type of genotoxicity: DNA damage and/or repair
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- GENETIC TOXICITY IN VIVO
- Author:
- Peter, H., Laib, R.J., Ottenwilder, H., Topp, H., Rupprich, N. and Bolt, H.M
- Year:
- 1 985
- Bibliographic source:
- Arch. of Toxicol. 57:84-87
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: In general conformance with OECD 482
- GLP compliance:
- not specified
- Type of assay:
- other: DNA Binding
Test material
- Reference substance name:
- Chloromethane
- EC Number:
- 200-817-4
- EC Name:
- Chloromethane
- Cas Number:
- 74-87-3
- Molecular formula:
- CH3Cl
- IUPAC Name:
- chloromethane
Constituent 1
Test animals
- Species:
- other: rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- exposure for 4 h of rats in a closed chamber; initial concentration approximately 2064 mg/m3 (1000 ppm) (reading off from graphs)
specific radioactivity: 13 mCi/mmol = 2.9 × 104 dpm/nmol
Administration / exposure
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- 4h
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1000ppm
Basis:
nominal conc.
- No. of animals per sex per dose:
- 5 animals per group
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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