Registration Dossier
Registration Dossier
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EC number: 203-812-5 | CAS number: 110-88-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with GLP, however no data pertaining to individual Draize score are available (Documentation insufficient for assessment)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Remarks:
- (Hoechst AG, Toxicology and Pathology)
Test material
- Reference substance name:
- 1,3,5-trioxane
- EC Number:
- 203-812-5
- EC Name:
- 1,3,5-trioxane
- Cas Number:
- 110-88-3
- Molecular formula:
- C3H6O3
- IUPAC Name:
- 1,3,5-trioxane
- Details on test material:
- - Name of test material (as cited in study report): Trioxane
- Physical state: crystals
- Analytical purity: 99.1%
- Impurities (identity and concentrations): ca. 0.1% Triethanolamine, ca. 0.8% water
- Storage condition of test material: 4 °C in dark
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG, Kastengrund
- Age at study initiation: ca. 3-5 months
- Weight at study initiation: 2.2-2.5 kg
- Diet (e.g. ad libitum): Altromin 2123 (ca. 15 g daily)
- Water (e.g. ad libitum): deionised water
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20±3
- Humidity (%): 50±20
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- physiological saline
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 500 mg (0.2 ml of physiol. saline was used to make paste) - Duration of treatment / exposure:
- 4 h
- Observation period:
- 30-60 min, 24, 48, and 72 h after removal of test substance
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- dorsal area of trunk was clipped 24h before application of test substance
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes with luke warm water
- Time after start of exposure: 4 h
Results and discussion
Any other information on results incl. tables
No irritation responses were observed, however no data pertaining to individual Draize score are available.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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