Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-996-5 | CAS number: 420-46-2
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study from reliable laboratory, report available
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1993
Materials and methods
- Principles of method if other than guideline:
- hepatocytes from male Sprague Dawley rat liver were isolated and exposed to atmospheres of HFC-143a for 4 days. At the end of the exposure, palmitoyl-CoA-oxidase activity was measured.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,1,1-trifluoroethane
- EC Number:
- 206-996-5
- EC Name:
- 1,1,1-trifluoroethane
- Cas Number:
- 420-46-2
- Molecular formula:
- C2H3F3
- IUPAC Name:
- 1,1,1-trifluoroethane
- Details on test material:
- Test material identified as Forane 143A in report
Constituent 1
Results and discussion
Any other information on results incl. tables
No increase in palmitoyl-CoA-oxidase activity was seen. It was concluded that HFC-143a is not a peroxisome inducer in vitro in rat hepatocytes in primary cultures treated for 4 days.
Applicant's summary and conclusion
- Conclusions:
- No increase in palmitoyl-CoA-oxidase activity was seen. It was concluded that HFC-143a is not a peroxisome inducer in vitro in rat hepatocytes in primary cultures treated for 4 days at exposure levels up to 80% in the atmosphere above the cells.
- Executive summary:
It was concluded that HFC-143a is not a peroxisome inducer in vitro in rat hepatocytes in primary cultures treated for 4 days at exposure levels up to 80% in the atmosphere above the cells when tested by measuring palmitoyl-CoA-oxidase activity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
