Registration Dossier
Registration Dossier
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EC number: 225-208-0 | CAS number: 4719-04-4
Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2005 - 2009
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Patch testing with formaldehyde and formaldehyde-releasers: multicentre study in Spain (2005–2009)
- Author:
- Latorre N, Borrego L, Fernandez-Redondo V et al.
- Year:
- 2 011
- Bibliographic source:
- Contact Dermatitis, 65, 286–292
Materials and methods
- Study type:
- case control study (retrospective)
- Endpoint addressed:
- skin sensitisation
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,2',2''-(hexahydro-1,3,5-triazine-1,3,5-triyl)triethanol
- EC Number:
- 225-208-0
- EC Name:
- 2,2',2''-(hexahydro-1,3,5-triazine-1,3,5-triyl)triethanol
- Cas Number:
- 4719-04-4
- Molecular formula:
- C9H21N3O3
- IUPAC Name:
- 2,2',2''-(1,3,5-triazinane-1,3,5-triyl)triethanol
Constituent 1
Method
- Type of population:
- other: Patients who underwent patch testing during 2005-2009 in six Spanish hospitals.
- Ethical approval:
- not applicable
- Details on study design:
- METHOD OF DATA COLLECTION
- Type: Record review
STUDY PERIOD: 2005 - 2009
STUDY POPULATION
- Total population (Total no. of persons in cohort from which the subjects were drawn): 7838 (902 were treated with the test substance)
- Selection criteria: From all patients that underwent patch testing during 2005 and 2009 those were selected, who reacted positive on formaldehyde and specific formaldehyde releasers e.g. the test substance.
HEALTH EFFECTS STUDIED
- other health effects: skin reactions - Exposure assessment:
- measured
- Details on exposure:
- TYPE OF EXPOSURE: Patch test with the test substance applied as 1 % solution in petrolatum.
Results and discussion
- Results:
- 8 patients of 902 showed a positive skin reaction when treated with the test substance (0.88%).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
