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EC number: 283-294-5
CAS number: 84604-16-0
Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Saccharomyces cerevisiae, Saccharomycelaceae.
The ability of Saccharomyces cerevisiae, Extract (Springer
0207/0 -MG-L) to induce skin irritation on a human three dimensional
epidermal model (EPISKIN Standard model (EPISKIN-SMTM)) was
tested. The possible skin irritation potential was tested through
topical application for 15 minutes.
Saccharomyces cerevisiae, Extract (Springer
0207/0 -MG-L) did interact with
3 -(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide
(MTT). In addition to the normal procedure, three killed tissues treated
with test substance and three killed non-treated tissues were used for
the cytotoxicity evaluation with MTT. The non-specific reduction of MTT
by Saccharomyces cerevisiae, Extract (Springer 0207/0-MG-L) was
0.33% of the negative control tissues. The net OD of the treated killed
tissues was subtracted from the ODs of the test substance treated viable
Skin irritation is expressed as the remaining cell viability after
exposure to the test substance. The relative mean tissue viability
obtained after 15 minutes treatment with Saccharomyces cerevisiae,
Extract (Springer 0207/0-MG-L) compared to the negative control tissues
was 108%. Since the mean relative tissue viability for Saccharomyces
(Springer 0207/0 -MG-L) was above 50% after 15 minutes treatment Saccharomyces
cerevisiae, Extract (Springer 0207/0-MG-L) is considered to be
The positive control had a mean cell viability of 8% after 15
minutes exposure. The absolute mean OD570(optical density at
570 nm) of the negative control tissues was within the laboratory
historical control data range. The standard deviation value of the
percentage viability of three tissues treated identically was less than
18%, indicating that the test system functioned properly.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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