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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Link to relevant study record(s)

Description of key information

 The reported 21-d NOEC of 0.17 mg/L for reproduction of Daphnia magna, as reported in the Key Study of Gersich et al. (1988) is used as key value in the aquatic hazard assessment.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
0.17 mg/L

Additional information

Two available studies are relevant to this information requirement, with only the study of Gersich et al. (1988) being suitably reliable for use in the chemical safety assessment. This study reports a 21-d flow-through reproduction toxicity test with Daphnia magna conducted in accordance with an in-house SOP of the Dow Chemical Company and GLP. The study reported a 21-d NOEC of 0.17 mg/L for both reproduction and mortality and will be used as a key study in the freshwater aquatic hazard assessment. The 21 -day NOEC value (reproduction) of 0.13 mg/L, reported by Ministry of Environment-Japan, is in good agreement with the Key Study. However, the reliability of this study cannot currently be assessed. No reliable studies were identified on saltwater species.