Registration Dossier
Registration Dossier
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EC number: 215-214-1 | CAS number: 1313-97-9
Endpoint summary
Administrative data
Description of key information
Additional information
Literature data exists on the bioaccumulation of soluble salts of light rare earth elements. Data on neodymium nitrate can be used to provide an estimate of the bioaccumulation potential of neodymium oxide.
The study shows that some bioaccumulation of light rare earth elements can occur but that elimination processes reduce the bioaccumulation factors over a period of time.
The highest BCF value observed during the study for neodymium was 634 in internal organs after 29 days and this reduced to 451 by the end of the study at 43 days. For the other studied tissues, the BCF values were the followings:
Muscle: BCF = 0.14 to 0.86
Skeleton: BCF = 0.24 to 2.28
Gills: BCF = 2.94 to 11.2
It is thus important to note the BCF values in internal organs were higher than that reported for other tissues. This was expected considering that the alimentary tract reflects normal transit of the substance. For this reason, this observation cannot be considered as an indication of bioaccumulation.
The CLP threshold to consider a substance as bioaccumulative is BCF ≥ 500. The REACH criteria for PBT and vPvB as stated in Annex XIII give cut-off BCF values of 2000 and 5000 respectively and it is therefore considered reasonable to assume that neodymium trinitrate, and by read-across the insoluble neodymium oxide, should not be considered to meet either of these criteria on the basis of the available data on an analogous substance. It is not considered necessary to undertake further bioaccumulation testing.
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