Registration Dossier
Registration Dossier
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EC number: 422-580-8 | CAS number: 75490-39-0 KHUSINIL
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EEC
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,2,4-trimethyl-4-phenyl-butane-nitrile
- EC Number:
- 422-580-8
- EC Name:
- 2,2,4-trimethyl-4-phenyl-butane-nitrile
- Cas Number:
- 75490-39-0
- Molecular formula:
- C13 H17 N
- IUPAC Name:
- 2,2-dimethyl-4-phenylpentanenitrile
Constituent 1
Test animals
- Species:
- other: Rabbit (New Zealand White)
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- other: Liquid substance used undiluted.
- Amount / concentration applied:
- 450 mg
- Duration of treatment / exposure:
- 4 h
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Reversibility:
- other: Not Applicable
- Irritation parameter:
- edema score
- Time point:
- other: Not Applicable
- Max. score:
- 0
- Remarks on result:
- other: Max. duration: 0 d; Max. value at end of observation period: 0 (related to all animals)
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Reversibility:
- other: Not Applicable
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Reversibility:
- other: Not Applicable
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Reversibility:
- other: Not Applicable
- Irritation parameter:
- erythema score
- Time point:
- other: Non Applicable
- Max. score:
- 0
- Remarks on result:
- other: Max. duration: 0 d; Max. value at end of observation period: 0 (related to all animals)
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Reversibility:
- other: Not Applicable
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Reversibility:
- other: Not Applicable
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
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