Registration Dossier
Registration Dossier
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EC number: 243-900-0 | CAS number: 20592-85-2
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Publication available for review, generally well documented, meets generally accepted scientific principles, acceptable for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Relationship between bone mineralization,|Ca absorption and plasma Ca in phosphonate-treated rats.
- Author:
- Treschel, U, Schenk, R, Bonjour, J-P, Russell, RGG and Fleisch, H
- Year:
- 1 977
- Bibliographic source:
- Am J Physiol, 232, E298 - 303
Materials and methods
- Type of study / information:
- Type: other: effects on bone
Test material
- Reference substance name:
- [nitrilotris(methylene)]trisphosphonic acid, sodium salt
- EC Number:
- 243-900-0
- EC Name:
- [nitrilotris(methylene)]trisphosphonic acid, sodium salt
- Cas Number:
- 20592-85-2
- Molecular formula:
- General formula C3H12NO9P3.xNa where x=3-5 ATMP-3Na C3H9NNa3O9P3 ATMP-4Na C3H8NNa4O9P3 ATMP-5Na C3H7NNa5O9P3
- IUPAC Name:
- Sodium salt of [nitrilotris(methylene)]trisphosphonic acid (3-5Na:1)
Constituent 1
Results and discussion
Any other information on results incl. tables
Neutralised ATMP (equivalent to 10 mg ATMP/kg bwt) resulted
in a non-significant 30% increase in the width of the
epiphyseal plate and inhibited mineralization of osteoid (n
= 4 animals).
Uptake of 45Ca from ligated intestine was unaffected by
neutralised ATMP (P<0.001; n = 37 animals).
There was no significant effect on plasma calcium following
2, 3 or 7 s.c. treatments with neutralised ATMP. Plasma
phosphate was decreased (13%; P<0.05) after the second
injection only (i.e. on day 3, prior to treatment).
Applicant's summary and conclusion
- Conclusions:
- ATMP produced marginal effects on skeletal mineralization and did not influence intestinal calcium uptake or plasma calcium values.
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