Registration Dossier
Registration Dossier
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EC number: 227-561-6 | CAS number: 5888-33-5
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
A study on hydrolysis and identification of the degradation products is not required.
1. In an extended OECD 301F study with Isobornyl acrylate 73,9% were degraded after 60 days, showing that the substance is non-persistent and inherently biodegradable.
2. Primary enzymatically degradation products are expected to be Isoborneol and acrylic acid which both are readily biodegradable:
The primary degradation step of Isobornyl acrylate in organisms is hydrolysis by carboxyl esterases which was shown in a non GLP in vivo study in rats (see chapter 7.1). This similar mechanism is expected to be one of the degradation steps in microorganisms. The primary metabolites acrylic acid and isoborneol are readily biodegradable (see chapter 5.2). Acrylic acid (CAS 79-10-7) attained 68% biodegradation within 14 days in an OECD 301 C (MITI-test) (JETOC 1992) and Isoborneol is also ecxpected to be readily biodegradable based on read across with Borneol (97 % biodegradation in a MITI test (MITI 1992).
Based on these informations persistence of Isobonyl acrylate is not expected and the expected degradation products acrylic acid and Isoborneol are known to be readily biodegradable. Therefore a study on hydrolysis and identification of the degradation products is not required.
Key value for chemical safety assessment
Additional information
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