Registration Dossier
Registration Dossier
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EC number: 255-449-7 | CAS number: 41583-09-9
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
No data with the target substance are available. A weight of evidence approach with the read across source substance melamine (CAS 108-78-1) from the consistent statements in two handbooks (Gmelin, 1971 and Ullmann, 2006) is applied. The hydrolysis rate was determined to be 0.95 d-1 at pH1.08 and 3.24 d-1 at pH14. Therefore and according to structural properties, hydrolysis is not expected/probable.
Key value for chemical safety assessment
Additional information
A weight of evidence approach with the source substance melamine (CAS 108-78-1) from the consistent statements in two handbooks (Gmelin, 1971 and Ullmann, 2006) is applied. Please refer section 13 for the read across justification of the test substance. Melamine is a stable molecule that is hydrolyzed only by mineral acid or inorganic alkali. Hydrolysis proceeds stepwise, with loss of one, two, or all three amino groups, i.e. producing ammeline, ammelide and cyanuric acid. The rate constants at 100 °C are: k(s-1) = 3.80 x 10exp-5 [OH-] respectively k(s-1) = 1.25 x 10-4[H+]. No data for relevant environmental conditions are available, probably because the substance hydrolyses only in the extreme pH ranges.
In the study (Gmelin, 1971) the hydrolysis rate was determined to be 0.95 d-1 at pH1.08 and 3.24 d-1 at pH14 (both values were determined at 100 °C). Therefore and according to structural properties, hydrolysis is not expected/probable.
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