Registration Dossier

Administrative data

Description of key information

In the key in vivo skin and eye irritation studies (WIL 1999c and WIL 1999d), tris(2-methoxyethoxy)vinylsilane was not irritant to rabbit skin or eyes. 

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

The key studies for in vivo skin and eye irritation were selected as the only available studies that were in accordance with OECD test guidelines and in compliance with GLP (WIL, 1999c and WIL, 1999d). They were therefore assigned Reliability 1. Supporting data from a non-guideline, non-GLP study for both endpoints confirm the conclusion of not irritant from the key studies.

Justification for classification or non-classification

On the basis of reliable in vivo skin and eye irritation data, tris(2 -methoxyethoxy)vinylsilane does not meet the criteria for classification as irritant according to EU Directive 67/548/EEC and Regulation 1272/2008.