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Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline stuy

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Objective of study:
other: hydrolysis study
Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD TG 111
Principles of method if other than guideline:
The test was performed according to the OECD Guidelines for Testing of Chemicals, Section 1 – Physical-Chemical Properties, OECD TG 111 (2004). As the hydrolysis was known to occur rapidly, hydrolysis behaviour of the test item in aqueous solutions was investigated in a Tier 1 test at room temperature instead of 50 °C, at pH 4, pH 7 and pH 9.

The hydrolysis behaviour was monitored by ion chromatography analysis with conductivity detection.


For further details see study endpoint summary of this study in IUCLID chapter 5.1.2.: hydrolysis.
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Thionyl dichloride
EC Number:
231-748-8
EC Name:
Thionyl dichloride
Cas Number:
7719-09-7
Molecular formula:
Cl2OS
IUPAC Name:
thionyl dichloride
Test material form:
other: liquid
Details on test material:
purity: 99.6%
Radiolabelling:
no

Test animals

Species:
other: not applicable - hydrolysis study
Strain:
other: not applicable - hydrolysis study

Administration / exposure

Route of administration:
other: not applicable - hydrolysis study
Vehicle:
other: not applicable - hydrolysis study
Duration and frequency of treatment / exposure:
not applicable - hydrolysis study
Doses / concentrations
Remarks:
Doses / Concentrations:
not applicable - hydrolysis study
No. of animals per sex per dose / concentration:
not applicable - hydrolysis study
Control animals:
other: not applicable - hydrolysis study

Results and discussion

Main ADME results
Type:
other: hydrolysis study in aqueous solution;
Results:
The hydrolysis half time (t 1/2) of thionyl dichloride is < 2 minutes at 23°C and different pH (4, 7 or 9)

Toxicokinetic / pharmacokinetic studies

Details on absorption:
not applicable - hydrolysis study
Details on distribution in tissues:
not applicable - hydrolysis study
Details on excretion:
not applicable - hydrolysis study

Bioaccessibility (or Bioavailability)

Bioaccessibility (or Bioavailability) testing results:
not applicable - hydrolysis study

Any other information on results incl. tables

Theoretical hydrolysis of Thionylchlorid:

SOCl2 + H2O -> 2 HCl + SO2

In the hydrolysis test solutions chloride and the water adduct / oxidation products sulfite and sulfate of the hydrolysis product sulfur dioxide were determined by ion chromatography.

Sulfur dioxide could not be detected by ion chromatography.

The test item shows rapid hydrolysis at pH 4, pH 7 and pH 9 within a few minutes.

Chloride, sulfite and sulfate as the only by ion chromatography detectable hydrolysis products were identified by comparison with the retention time of the calibration substances.

The concentrations of the formed chloride in the hydrolysis test solutions were determined by external calibration method and correspond to the theoretical values assuming a complete degradation of the test item (recovery 99.1 to 102.4 %). Sulfite and sulfate were quantified accordingly. Recoveries were in the range of 80 to 95 %.

Losses of sulphur might be explained by the evaporation of gaseous sulphur dioxide.

Due to the observed immediately and complete degradation (100 %) of the test item between sample preparation time and injection time by ion chromatography, the following half-life time and hydrolysis rate was calculated at 23 °C (room temperature) and pH 4, pH 7 and pH 9.

Test at 23 °C and pH 4: Half-life-time: t(1/2) = 72 seconds

                           Hydrolysis rate constant: k = 9.59410 x 10E-3 per sec

                    The half-life time is set to: t ½ < 2 minutes

Test at 23 °C and pH 7: Half-life-time: t(1/2) = 72 seconds

                    Hydrolysis rate constant: k = 9.59410 x 10E-3 per sec

                    The half-life time is set to: t ½ < 2 minutes

Test at 23 °C and pH 9: Half-life-time: t(1/2) = 54 seconds

                    Hydrolysis rate constant: k = 1.27921 x 10E-2 per sec

                    The half-life time is set to: t ½ < 2 minutes

Applicant's summary and conclusion

Executive summary:

The test was performed according to the OECD Guidelines for Testing of Chemicals, Section 1 – Physical-Chemical Properties, OECD TG 111 (2004). As the hydrolysis was known to occur rapidly, hydrolysis behaviour of the test item in aqueous solutions was investigated in a Tier 1 test at room temperature instead of 50 °C, at pH 4, pH 7 and pH 9.

The hydrolysis behaviour was monitored by ion chromatography analysis with conductivity detection.

The hydrolysis half time (t 1/2) at 23°C and pH 4, pH 7, and pH 9 is < 2 minutes

For further details see study endpoint summary of this study in IUCLID chapter 5.1.2.: hydrolysis.