Registration Dossier
Registration Dossier
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EC number: 204-337-6 | CAS number: 119-61-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Only results given (methodical details missing)
Data source
Reference
- Reference Type:
- publication
- Title:
- Monographs on fragrance raw materials: Benzophenone
- Author:
- Opdyke DLJ
- Year:
- 1 979
- Bibliographic source:
- Food Cosmet Toxicol 11, 873-874
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method not further specied
- GLP compliance:
- no
- Test type:
- other: not further specified
Test material
- Reference substance name:
- Benzophenone
- EC Number:
- 204-337-6
- EC Name:
- Benzophenone
- Cas Number:
- 119-61-9
- Molecular formula:
- C13H10O
- IUPAC Name:
- diphenylmethanone
- Details on test material:
- - Name of test material (as cited in study report): Benzophenone
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not further specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- not further specified
- Duration of exposure:
- not further specified
- Doses:
- not further specified
- No. of animals per sex per dose:
- not further specified
- Control animals:
- not specified
- Details on study design:
- not further specified
- Statistics:
- not further specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 535 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 2 007 - <= 6 226
- Mortality:
- not further specified
- Clinical signs:
- other: not further specified
- Gross pathology:
- not further specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The acute dermal toxicity (LD50) in rabbits was reported to be at 3535 mg/kg bw.
- Executive summary:
In this review the dermal LD50 value for benzophenone in rabbits was given with 3535 mg/kg bw. Thus benzophenone is practically non-toxic in the rabbit after a single dermal dose and is thus not subject of classification.
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