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Diss Factsheets
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EC number: 204-337-6 | CAS number: 119-61-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Aquatic acute toxicity testing using the nematode Caenorhabditis elegans
- Author:
- Ura K, Kai T, Sakata S, Iguchi T, Arizono K
- Year:
- 2 002
- Bibliographic source:
- J Health Sci 48: 583-586 (2002)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- An acute toxicity test was performed according to a procedure of Donkin and Williams (1995). Ten worms (1-day-old larvae) each were dispensed into 24-well tissue culture plates containing 0.5 mL of K-medium and for example benzophenone. All treatments were done in triplicate. No feed was given during the test. The worms were exposed for 24 hr at 20°C and the number of dead worms was determined.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzophenone
- EC Number:
- 204-337-6
- EC Name:
- Benzophenone
- Cas Number:
- 119-61-9
- Molecular formula:
- C13H10O
- IUPAC Name:
- diphenylmethanone
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test substrate
- Vehicle:
- yes
- Details on preparation and application of test substrate:
- - Controls: performed
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): DMSO
- Concentration of vehicle in test medium (stock solution and final test solution): <=1%
- Evaporation of vehicle before use: no
Test organisms
- Test organisms (species):
- Caenorhabditis elegans
- Animal group:
- nematods
- Details on test organisms:
- TEST ORGANISM
- Common name: nematode (Caenorhabditis elegans)
- Source: wild type N2 strain
- Age at test initiation (mean and range, SD): 1d
- Weight at test initiation (mean and range, SD): not reported
ACCLIMATION: not reported
Study design
- Study type:
- laboratory study
- Substrate type:
- other: K-medium
- Limit test:
- no
- Total exposure duration:
- 24 h
Test conditions
- Test temperature:
- 20°C
- Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 56.8 other: mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95% c.i.: 52.1-62.1 mg/L
- Reported statistics and error estimates:
- The median lethal concentration (LC50) was calculated using the PROBIT method.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- In a static 24 h toxicity test, a LC50=56.8 mg/L (nominal) was determined for the nematode Caenorhabditis elegans.
- Executive summary:
An acute toxicity test was performed according to a procedure of Donkin and Williams (1995). Ten worms (1-day-old larvae) each were dispensed into 24-well tissue culture plates containing 0.5 mL of K-medium and for example benzophenone. All treatments were done in triplicate. No feed was given during the test. The worms were exposed for 24 hr at 20°C and the number of dead worms was determined.
In this static 24 h toxicity test, a LC50=56.8 mg/L (nominal) was determined for the nematode Caenorhabditis elegans.
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