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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Description of key information

According to Annex IX, Section 9.3.2 column 2 of REACH Regulation (EC) No 1907/2006 a study on bioaccumulation need not to be conducted, if the substance has a low potential for bioaccumulation (for instance a log Kow ≤ 3) and/or a low potential to cross biological membranes. The retrieved logPow of 1.78 is below the threshold value of 4 (according to GHS criteria) and thus, accumulation in organisms of the test substance is not expected.

Key value for chemical safety assessment

Additional information

In ECHA's Guidance Document on information requirements and chemical safety assessment Chapter R.7c (R.7.10.3.4, p. 23ff) and Chapter R.11 (R.11.1.3.2, p. 27f) it is laid out that several substance properties (e.g. logPow, molecular size of substance) can be combined in a weight of evidence approach to evaluate the substance's bioaccumulation potential.

The evaluation of physico-chemical substance properties resulted in measured values of the test substance’s water (0.005 mg/L) and octanol solubility (0.3 mg/L) which were used for the calculation of logPow. The retrieved logPow of 1.78 is below the threshold value of 4 (according to GHS criteria) and thus, accumulation in organisms of the test substance is not expected.

Another supporting indicator is the molecular diameter (2.05 nm) of the test substance. This value exceeds the established threshold limit for molecular diameters (1.7 nm) which results in the failure of the molecule to cross cell membranes because it is simply too bulky to do so.

Taking all available information mentioned above into account, it can be expected hat the substance has a low bioaccumulation potential.