Registration Dossier

Administrative data

Endpoint:
biotransformation and kinetics
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1999
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Abstract from Symposium

Data source

Reference
Reference Type:
review article or handbook
Title:
Higher alcohols bioconcentration: Influence of Biotransformation
Author:
Watze De Wolf and Tom Parkerton
Year:
1999
Bibliographic source:
217th ACS National Meeting, Anaheim,CA Symposium 'Persistent, Bioaccumulative, Toxic Chemicals'

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other:
Deviations:
yes
Principles of method if other than guideline:
Made use of OECD 305 guideline
GLP compliance:
yes
Remarks:
Stated in the abstract
Type of medium:
aquatic

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

Water analysis showed that exposure concentrations were maintained relatively constant during the uptake phase. The uptake phase showed the fish attained rapid and steady state concentration of the alcohol. Rapid elimination occured after transfer to clean water. Measurement of the BCF values at the lower water concentration tested were 16, 29 and 30 for C10 , C12 and C13 -alcohol. Measured BCF values were dependant on water concentration with a two-fold increase observed for the C12 and C13 alcohol.

Applicant's summary and conclusion

Conclusions:
The results of bioconcentration testing in fish clearly showed lack of any substantial bioconcentration of the C10, C12 and C13 alcohols tested. The BCF value were 16, 29 and 30 , respectively. Isotridecanol (C13) is closely related to this group of alcohols, and although the information is taken from a scientific abstract, it is considered adequate to support the non PBT status of Isotridecanol.
Executive summary:

The results of bioconcentration testing in fish clearly showed lack of any substantial bioconcentration of the C10, C12 and C13 alcohols tested. The BCF value were 16, 29 and 30 , respectively. Isotridecanol (C13) is closely related to this group of alcohols, and although the information is taken from a scientific abstract, it is considered adequate to support the non PBT status of Isotridecanol.