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Ecotoxicological information

Toxicity to soil macroorganisms except arthropods

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Endpoint:
toxicity to soil macroorganisms except arthropods: long-term
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Recent, non-GLP published study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
according to guideline
Guideline:
OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
GLP compliance:
no
Analytical monitoring:
not specified
Details on sampling:
No details.
Vehicle:
no
Details on preparation and application of test substrate:
Four fluorides were applied into the soil in sublethal concentrations.
Test organisms (species):
Eisenia fetida
Details on test organisms:
No further details on test organism.
Study type:
laboratory study
Substrate type:
not specified
Limit test:
no
Total exposure duration:
22 wk
Post exposure observation period:
No post exposure observation period.
Test temperature:
Not stated
pH:
Not stated
Moisture:
Not stated
Details on test conditions:
No further details given.
Nominal and measured concentrations:
nominal
Reference substance (positive control):
no
Duration:
22 wk
Dose descriptor:
NOEC
Effect conc.:
1 200 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth
Remarks on result:
other: Sodium fluoride
Duration:
22 wk
Dose descriptor:
NOEC
Effect conc.:
750 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth
Remarks on result:
other: Potassium fluoride
Details on results:
In higher concentrations sodium fluoride, potassium fluoride and the sodium salt of fluoroacetic acid reduced growth of E.fetida significantly. Calcium fluoride had no effect. The maturity was delayed through higher concentrations of NaF and KF in the substrate. Most cocoons were found in the experiment with the sodium salt of fluoro acetic acid. Small concentrations of sodium fluoride and potassium fluoride reduced it. Only sodium fluoride reduced the number of hatchlings per cocoon significantly. At the end of the test, all worms from the variants with sodium fluoride, potassium fluoride and calcium fluoride had a significant higher fluoride concentration.
Results with reference substance (positive control):
Not relevant
Reported statistics and error estimates:
No reported statistics and error estimates.

At higher concentrations sodium fluoride, potassium fluoride and the sodium salt of fluoroacetic acid reduced the growth of E. fetida significantly. Calcium fluoride had no effect. The rate of maturity of the earthworms was also significantly reduced when sodium fluoride and potassium fluoride was used. The number of hatchlings was reduced in the presence of sodium fluoride, while the number of cocoons was reduced in the presence of a low concentration of sodium fluoride and potassium fluoride.

No data is available on the effects of hydrogen fluoride on the growth, maturity and and fertility of the earthworm. However, the submission substance will be unstable in the terrestrial environment and exposure of terrestrial organisms will predominantly be to fluoride ions. Therefore the results above are a good indication of the behaviour of hydrogen fluoride in the terrestrial environment.

Validity criteria fulfilled:
not applicable
Conclusions:
In higher concentrations sodium fluoride, potassium fluoride and the sodium salt of fluoroacetic acid reduced the growth of E.fetida significantly. Effects on the maturity and fertility of the earthworms was also noted in the presence of sodium fluoride and potassium fluoride.
Executive summary:

The toxicity of various fluoride compounds to Eisenia fetida was investigated over a period of 22 weeks. At higher concentrations sodium fluoride, potassium fluoride and the sodium salt of fluoroacetic acid reduced significantly. Calcium fluoride had no effect. The rate of maturity of the earthworms was also significantly reduced when sodium fluoride and potassium fluoride was used. The number of hatchlings was reduced in the presence of sodium fluoride, while the number of cocoons was reduced in the presence of a low concentration of sodium fluoride and potassium fluoride.

No data is available on the effects of hydrogen fluoride on the growth, maturity and and fertility of the earthworm. However, in a terrestial environment the submission substance exists predominantly as fluoride ions. Therefore the results above are a good indication of the behaviour of hydrogen fluoride in the terrestial environment.

Endpoint:
toxicity to soil macroorganisms except arthropods: long-term
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
Dihydrogen hexafluorotitanate is an inorganic substance which will rapidly dissociate into fluoride, hydrogen and titanium ions upon dissolution in the environment. However, hydrogen and titanium ions do not remain as such in solution, only fluoride ions do. The approach follows scenario 1 of the RAAF (ECHA 2017).

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Source
sodium fluoride (CAS 7681-49-4)
potassium fluoride (CAS 7789-23-3)
Target
Dihydrogen hexafluorotitanate (CAS 17439-11-1)

3. ANALOGUE APPROACH JUSTIFICATION
Since dihydrogen hexafluorotitanate rapidly dissociates into fluoride, hydrogen and titanium ions upon dissolution in the environment, and only fluoride but not hydrogen and titanium ions will remain as such in solution, it can be assumed that toxicity (if any) will be driven by the fluoride anion. Therefore, the NOEC of 1200 mg F/kg for the long-term (154 days) toxicity (growth, maturity and hatchability of coccons) of sodium fluoride to Eisenia fetida (according to OECD 207) is read-across resulting in a NOEC of 1725.5 mg/kg for dihydrogen hexafluorotitanate.

4. DATA MATRIX
see attached read-across statement in section 13.2
Reason / purpose for cross-reference:
read-across source
Duration:
22 wk
Dose descriptor:
NOEC
Effect conc.:
1 200 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth
Remarks on result:
other: Sodium fluoride
Duration:
22 wk
Dose descriptor:
NOEC
Effect conc.:
750 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth
Remarks on result:
other: Potassium fluoride
Details on results:
In higher concentrations sodium fluoride, potassium fluoride and the sodium salt of fluoroacetic acid reduced growth of E.fetida significantly. Calcium fluoride had no effect. The maturity was delayed through higher concentrations of NaF and KF in the substrate. Most cocoons were found in the experiment with the sodium salt of fluoro acetic acid. Small concentrations of sodium fluoride and potassium fluoride reduced it. Only sodium fluoride reduced the number of hatchlings per cocoon significantly. At the end of the test, all worms from the variants with sodium fluoride, potassium fluoride and calcium fluoride had a significant higher fluoride concentration.
Results with reference substance (positive control):
Not relevant
Reported statistics and error estimates:
No reported statistics and error estimates.

At higher concentrations sodium fluoride, potassium fluoride and the sodium salt of fluoroacetic acid reduced the growth of E. fetida significantly. Calcium fluoride had no effect. The rate of maturity of the earthworms was also significantly reduced when sodium fluoride and potassium fluoride was used. The number of hatchlings was reduced in the presence of sodium fluoride, while the number of cocoons was reduced in the presence of a low concentration of sodium fluoride and potassium fluoride.

No data is available on the effects of hydrogen fluoride on the growth, maturity and and fertility of the earthworm. However, the submission substance will be unstable in the terrestrial environment and exposure of terrestrial organisms will predominantly be to fluoride ions. Therefore the results above are a good indication of the behaviour of hydrogen fluoride in the terrestrial environment.

Validity criteria fulfilled:
not applicable
Conclusions:
In higher concentrations sodium fluoride, potassium fluoride and the sodium salt of fluoroacetic acid reduced the growth of E.fetida significantly. Effects on the maturity and fertility of the earthworms was also noted in the presence of sodium fluoride and potassium fluoride.
Executive summary:

The toxicity of various fluoride compounds to Eisenia fetida was investigated over a period of 22 weeks. At higher concentrations sodium fluoride, potassium fluoride and the sodium salt of fluoroacetic acid reduced significantly. Calcium fluoride had no effect. The rate of maturity of the earthworms was also significantly reduced when sodium fluoride and potassium fluoride was used. The number of hatchlings was reduced in the presence of sodium fluoride, while the number of cocoons was reduced in the presence of a low concentration of sodium fluoride and potassium fluoride.

No data is available on the effects of hydrogen fluoride on the growth, maturity and and fertility of the earthworm. However, in a terrestial environment the submission substance exists predominantly as fluoride ions. Therefore the results above are a good indication of the behaviour of hydrogen fluoride in the terrestial environment.

Description of key information

Since dihydrogen hexafluorotitanate rapidly dissociates into fluoride, hydrogen and titanium ions upon dissolution in the environment, and only fluoride but not hydrogen and titanium ions will remain as such in solution, it can be assumed that toxicity (if any) will be driven by the fluoride anion. Therefore, the NOEC of 1200 mg F/kg for the long-term (154 days) toxicity (growth, maturity and hatchability of coccons) of sodium fluoride to Eisenia fetida (according to OECD 207) is read-across resulting in a NOEC of 2828.5 mg/kg for dihydrogen hexafluorotitanate (based upon a molecular weight conversion and correction to max. purity).

Key value for chemical safety assessment

Long-term EC10, LC10 or NOEC for soil macroorganisms:
2 828.5 mg/kg soil dw

Additional information

Dihydrogen hexafluorotitanate


Since dihydrogen hexafluorotitanate rapidly dissociates into fluoride, hydrogen and titanium ions upon dissolution in the environment, and only fluoride but not hydrogen and titanium ions will remain as such in solution,it can be assumed that toxicity (if any) will be driven by the fluoride anion. Therefore, full read-across of soil toxicity data of potassium fluoride (CAS #7789-23-3) and other fluorides based upon a molecular weight conversion (and correction to max. purity) is justified (see below).


 


Fluorides


The toxicity of various fluoride compounds to Eisenia fetida was investiated over a period of 22 weeks. At higher concentrations sodium fluoride, potassium fluoride and the sodium salt of fluoroacetic acid reduced significantly. Calcium fluoride had no effect. The rate of maturity of the earthworms was also significantly reduced when sodium fluoride and potassium fluoride was used. The number of hatchlings was reduced in the presence of sodium fluoride, while the number of cocoons was reduced in the presence of a low concentration of sodium fluoride and potasium fluoride (Vogel & Ottow, 1992).