Registration Dossier
Registration Dossier
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EC number: 200-554-5 | CAS number: 63-05-8
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05 to 14 Oct 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.7
- Temp.:
- 25 °C
- pH:
- 7
- Conclusions:
- The partition coefficient (log Pow) of the substance is 2.7 at 25 °C and pH 7.
- Executive summary:
The n-octanol/water partition coefficient of the test item was determined at 25 °C following OECD Testing Guideline 117 (HPLC method) to be 2.7 at 25 °C and pH 7. This method is based on the correlation of the reversed phase retention data of the test compound with those of reference compounds with known log Pow values.
Reference
Validity criteria for the measurement of the partition coefficient:
| Target condition according to guideline: | Actual condition according to the study: | Validity criteria met: |
| In order to correlate the measured HPLC data of a compound with its P value, a calibration graph of log P vs. chromatographic data using at least 6 reference points has to be established. | A calibration graph with six reference points is available. | Yes |
| Whenever possible, at least one reference compound should have a Pow above that of the test substance, and another a Pow below that of the test substance. | LogPows of the test substance = 2.73 LogPows of reference compounds = 0.3 - 4.9 | Yes |
| HPLC method: the result of the preliminary estimation should be stated. | The result of the preliminary estimation is stated. | Yes |
Description of key information
The partition coefficient (log Pow) of Androst-4-ene-3, 17-dione is 2.7 at 25°C and pH 7.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.7
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
