Registration Dossier
Registration Dossier
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EC number: 270-478-5 | CAS number: 68442-22-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The following information was taken into account for any hazard / risk assessment, and the tests were conducted on an analog substance, EC 283 -392 -8:
i) the ability to induce mutations in bacterial (AMES, OECD 471)
ii) in mammalian cells (in vitro tk+/- mouse lymphoma assay, similar to OECD 476);
iii) chromosome aberration (in vivo mouse micronucleus assay, OECD 474)
Negative results were obtained in the AMES assay.
Negative results were obtained in the mouse lymphoma assay.
Negative results were obtained from the in vivo micronucleus tests.
The weight of evidence suggests that the test material EC 270 -478 -5 is non-clastogenic and non-mutagenic.
Short description of key information:
EC 270-478-5 has not been tested for genotoxicity, however experimental data from the structurally related substance EC 283-382-8 was available and suitable for read-across.
AMES: negative in SALMONELLA (with and without metabolic activation)
tk+/- mouse lymphoma in-vitro assay: negative
in-vivo: there was no evidence of increase in the number of micronuclei per 1000 polychromatic erythrocytes in Mammalian Erythrocyte Micronuclues Test in mice.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
In accordance with EU CLP (Regulation (EC) No. 1272/2008) classification is not required for genotoxicity.
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