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EC number: 270-302-7
CAS number: 68424-43-1
There were no deaths. No signs of systemic toxicity
were noted in the test or control animals during the test.
Bodyweight changes of the test animals between
Day 1 and Day 6 were comparable to those observed in the corresponding
control group animals over the same period.
study was performed to assess the skin sensitisation potential of the
test material in the CBA/Ca strain mouse following topical application
to the dorsal surface of the ear. The method was designed to meet the
requirements of the following:
Guideline for the Testing of Chemicals No. 429 "Skin Sensitisation:
Local Lymph Node Assay" (adopted 24 April 2002)
B42 Skin Sensitisation (Local Lymph Node Assay) of CommissionRegulation
(EC) No. 440/2008
a preliminary screening test in which no clinical signs of toxicity were
noted at a concentration of50% w/w, this concentration was selected as
the highest dose investigated in the main test of the Local Lymph Node
Assay. Three groups, each of four animals, were treated with 50 µl
(25 µl per ear) of the test material as asolutionindimethyl formamideat
concentrations of50%,25% or10% w/w. A further group of four animals was
treated withdimethyl formamidealone.
Stimulation Index expressed as the mean radioactive incorporation for
each treatment group divided by the mean radioactive incorporation of
the vehicle control group are as follows:
Concentration (%w/w) indimethyl formamide
test material was considered to be a non-sensitiserunder the conditions
of the test.
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