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EC number: 270-302-7
CAS number: 68424-43-1
study was performed to assess the acute dermal toxicity of the test item
in the Wistar strain rat. The method was designed to meet the
requirements of the following:
Guidelines for the Testing of Chemicals No. 402 “Acute Dermal Toxicity”
(adopted 24 February 1987)
B3 Acute Toxicity (Dermal) of CommissionRegulation (EC) No. 440/2008
group of ten animals (five males and five females) was given a single,
24‑Hour, semi‑occluded dermal application of the test item to intact
skin at a dose level of 2000 mg/kg bodyweight. Clinical signs and
bodyweight development were monitored during the study. All animals were
subjected to gross necropsy.
Mortality. There were
Clinical Observations. Due
to possible ingestion of test item, signs of systemic toxicity noted in
one female animal were hunched posture, lethargy, gasping respiration,
decreased respiratory rate and pallor of the extremities. There were no
other signs of systemic toxicity noted.
Dermal Irritation. Very
slight erythema was noted at the test sites of all animals.
showed expected gains in bodyweight over the study period except for
three females which showed bodyweight loss or no gain in bodyweight
during the first week with expected gain in bodyweight during the second
abnormalities were noted at necropsy.
Conclusion. The acute
dermal median lethal dose (LD50) of the test item in the
Wistar strain rat was found to be greater than 2000 mg/kg bodyweight.
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