Tricyclo[3.3.1.13,7]decane-1-acetic acid, .alpha.-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxy-, (.alpha.S)-

Flammability

Administrative data

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

15- 21 January 2004

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2004

Report date:

2004

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method A.10 (Flammability (Solids))

Deviations:

no

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

(2S)-2-{[(tert-butoxy)carbonyl]amino}-2-(3-hydroxyadamantan-1-yl)acetic acid

EC Number:

700-361-0

Cas Number:

361442-00-4

Molecular formula:

C17H27NO5

IUPAC Name:

(2S)-2-{[(tert-butoxy)carbonyl]amino}-2-(3-hydroxyadamantan-1-yl)acetic acid

Constituent 2

Reference substance name:

1-Hydroxyadamantanyl-3-(S)-Boc-glycine

IUPAC Name:

1-Hydroxyadamantanyl-3-(S)-Boc-glycine

Details on test material:

cream solid, recieved by laboratory on 19-December-2003, storage : room temperature . The mean moisture content of the test material was also confirmed by the testing laboratory (0.2%).

Results and discussion

Flammable solids

Test procedure:

burning time (test type not further specified)

Remarks:

or specified in description of method (migrated information)

Burning time:

395 s

Pyrophoric solids

Test procedure:

ignition time on contact with air

Remarks:

Ignition on contact with air refers to either Pyrophoric solids or Pyrophoric liquids depending on physical state (migrated information).

Remarks on result:

no ignition on contact with air (not further specified)

Remarks:

corresponding to 'no' in migrated source record.

Pyrophoric liquids

Test procedure:

ignition time on contact with air

Remarks:

Ignition on contact with air refers to either Pyrophoric solids or Pyrophoric liquids depending on physical state (migrated information).

Remarks on result:

no ignition on contact with air (not further specified)

Remarks:

corresponding to 'no' in migrated source record.

Any other information on results incl. tables

In an initial test, the test material ignited very easily and quickly after 10 seconds and the flame burned for 4 minutes 12 seconds. The test substance burned with a yellow/orange flame and a small amount of black smoke was produced. Only a small amount of unburned test substance remained. In the second test, it took 6 minutes 35 seconds for the 200 mm train to burn. This meant that no further work was necessary and the test substance is not classified as highly flammable. The moisture content was recorded as a mean of 0.2 %.

Applicant's summary and conclusion

Interpretation of results:

other: not highly flammable

Conclusions:

The test material ignited with a yellow/orange flame and a small amount of black smoke was produced in both the preliminary screening and main test. The test material burned for 395 seconds in the main test. Based on this finding the test material has been determined to be not highly flammable.

Executive summary:

The objective of this study is to determine the flammability (solids) of the test material in accordance with Method A10 of Commission Directive 92/69/EEC. The study was assigned a reliability of 1 and followed acceptable OECD, EU or recognized standards and was in accordance with GLP.

The flammability (solids) of BMS 528233-01 was determined by measuring the burning rate of test material prepared as a pile of set dimensions.

The test material ignited with a yellow/orange flame and a small amount of black smoke was produced in both the preliminary screening and main test. The test material burned for 395 seconds in the main test. Based on this finding the test material has been determined to be not highly flammable.