Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 239-937-7
CAS number: 15834-04-5
No toxic effects to freshwater fish up to the limit of water solubility.
In accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read
across to four structurally related category members pentaerythritol
tetraesters of n-decanoic, n-heptanoic, n-octanoic and n-valeric acids
(CAS-No. 68424-31-7), decanoic acid, mixed esters with heptanoic acid,
octanoic acid, pentaerythritol and valeric acid (CAS No. 71010-76-9),
fatty acids, C5-9 tetraesters with pentaerythritol (CAS 67762-53-2) and
fatty acids, C8-10 mixed esters with dipenaterythritol, isooctanoic
acid, pentaerythritol and tripentaerythritol (CAS 189-200-42-8) in order
to fulfil the data requirements according to Annex VII-IX. This
read-across is justified in detail in the overall summary (IUCLID
chapter 6.1) and within the category justification in IUCLID Section 13.
In this case of read-across, the best suited (highest degree of
structural similarity, nearest physico-chemical properties) read-across
substances were used for the assessment. All read-across substances have
the same alcohol component, i.e. pentaerythritol (CAS 189200-42-8
additionally contains dipenaterythritol and tripentaerythritol), and are
tetra-esters with a fatty acid chain length within the range of C5 – C10
comparable to the target substance with chain length of C5.
In the first key study, the short term toxicity of CAS 68424-31-7 to
freshwater fish was investigated in a semi-static limit test (Combert
and Caunter, 1991) conducted according to a guideline similar to OECD
203 using Salmo gairdneri as a test organism. This study determined LC50
(96h) > 1000 mg/L (nominal). The test material did not dissolved
completely in the dilution water. No mortality was observed within the
tested concentration (1000 mg/l nominal) during 96h exposure under test
conditions. Based on these results it can be concluded that no
toxicological effects on freshwater fish are expected up to limit of
In a further study with decanoic acid, mixed esters with heptanoic acid,
octanoic acid, pentaerythritol and valeric acid (CAS No. 71010-76-9) the
short-term toxicity to freshwater fish was investigated according to
OECD 203 under static conditions using Brachydanio rerio as test
organism (Lili, 2009). Nominal test concentrations of 100 and 150 mg/L
were applied. Test substance monitoring using TOC analysis measured test
concentrations of 0.696 and 0.704 mg/L, respectively. Undissolved test
material was not removed from the test system; however, this is
considered negligible, because no mortality was observed in any
treatment and the control throughout the test period of 96 h. Hence, the
96 h-LC50 is determined to be > 0.704 mg/L (measured value, arithmetic
mean) and thus above the limit of water solubility (< 0.02 mg/L).
Furthermore, short-term toxicity of fatty acids, C5-9 tetraesters with
pentaerythritol (CAS 67762-35-2) to freshwater fish was investigated in
a study according to OECD 203 under static conditions using Cyprinus
carpio as test organism (Migchielsen, 2012). A nominal test
concentration of 100 mg/L (prepared as WAF) was applied. Test substance
monitoring measured a concentration of 4.8 mg/L. The final test solution
was slightly hazy with a floating layer; however, this is considered
negligible, because no mortality was observed in the treatment
throughout the test period of 96 h. Hence, the 96 h-LL50 is determined
to be > 100 mg/L (nominal) and > 4.8 mg/L (measured) and thus above the
limit of water solubility (< 0.006 mg/L, purified water).
In addition, an acute study with fatty acids, C8-10 mixed esters with
dipenaterythritol, isooctanoic acid, pentaerythritol and
tripentaerythritol (CAS 189200-42-8) was conducted according to EPA OTS
797.1400 (fish acute toxicity test, 1987) under semi-static conditions
using Pimephales promelas as test organism (Targia, 1994). The
monitoring of the test substance concentrations confirmed that the
substance is poorly soluble in water. As the test substance
concentration was not found to be stable during the test, the effect
values are related to the nominal concentration. Hence, the 96 h-LC50 is
determined to be > 5 mg/L (nominal) and thus above the limit of water
solubility (< 0.15 mg/L).
Based on these results from structurally related read-across substances
(in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are
characterized by a similar ecotoxicological profile, it can be concluded
that 2,2-bis[[(1-oxopentyl)oxy]methyl]propane-1,3-diyl divalerate
(CAS-No.15834-04-5) will not exhibit short-term toxic effects to
freshwater fish up to the limit of water solubility.
As it can be seen in the data matrix of the category justification in
section 13 and the overall summary, all reliable data in the category
support the hazard assessment of each category member by showing a
consistent pattern of results; no toxicological effects up to the limit
of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Tällä verkkosivustolla käytetään evästeitä parhaan mahdollisen käyttäjäkokemuksen varmistamiseksi.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again