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Description of key information

The upper airway sensory irritation potential of isodecanol has been evaluated in male Swiss Webster mice.  Respiratory rates were monitored throughout the exposure.  There were no deaths during the exposure or the following observation period.  There was no evidence of pulmonary irritation and none of the animals in either group showed ocular abnormalities.  

Additional information

The upper airway sensory irritation potential of isodecanol has been evaluated in male Swiss Webster mice.  Four mice per group received head-only exposures for 30 minutes to the test substance generated as a vapour at 111 and 168 ppm, 93 and 141 mg/l, respectively.  Respiratory rates were monitored throughout the exposure.  There were no deaths during the exposure or the following observation period.  There was no evidence of pulmonary irritation and none of the animals in either group showed ocular abnormalities.  The vapour concentration of 111 ppm resulted in a 32% decrease in breathing rate and the concentration of 168 resulted in a 40% decrease in breathing rate.  It is concluded that the approximate RD50 value in this study is 280 ppm.