Benzyl-C12-14-alkyldimethylammonium chlorides

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Study period:

From March 15, 2012 to March 19, 2012

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

KL2 due to RA

Justification for type of information:

Refer to the Quaternary ammonium salts (QAS) category or section 13 of IUCLID for details on the category justification.

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7950 (Vapor Pressure)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: by loss of weight or by trapping vaporisate

Key result

Temp.:

ca. 20 °C

Vapour pressure:

< 0.002 Pa

Temp.:

ca. 20 °C

Vapour pressure:

< 0 mm Hg

Key result

Temp.:

ca. 25 °C

Vapour pressure:

< 0.006 Pa

Temp.:

ca. 25 °C

Vapour pressure:

< 0 mm Hg

Formulas used:

Evaporation rate: (νT) =Dm/ F x t [g/cm /h]

where:

Dm = weight loss of the test substance [g]

F = surface of the sample plate [cm2]

t = elapsed time for the weight loss [h]

Vapour pressure equation log PT=c lognT+d

where:

c = constant specific for the experimental arrangement

d = constant specific for the experimental arrangement

Vapour pressure regression curve log PT=a 1/T+b

where:

T = temperature [K]

a = slope [K]

b = intercept

Results:

The isothermal TGA effusion method was applied for the determination of the vapour pressure of the test substance is:

The vapour pressure of the test substance at 20°C (293K) and 25°C (298K) was:   20°C 25°C [Pa] [mmHg] [Pa] [mmHg] Test substance < 1.5 x10^-3 < 1.1 x10^-5 < 5.8 x10-^3 < 4.3 x10^-5

Conclusions:

Under the study conditions, the vapour pressure of read across substance was found to be <1.5E-03 Pa at 20°C and <5.8E-03 Pa at 25°C (isothermal thermo gravimetric effusion method).

Executive summary:

A study was conducted to determine the vapour pressure of the read across substance, C12-16 ADBAC (purity: 99.2%) according to OECD Guideline 104, EU Method A.4 and EPA OPPTS 830.7950 (isothermal thermo gravimetric effusion method), in compliance with GLP. Approximately 14.5 or 15.2 mg of the read across substance was applied to the surface of a roughened glass plate as a homogeneous layer. The plates were dried at 30°C under nitrogen in the thermogravimetric analyzer (TGA). The weight loss of the read across substance was measured continuously as a function of time. Benzo(ghi)perylene, chrysene, hexachlorobenzene, naphthalene and water were used as reference substances for validation. The log Vt, 20 value which was obtained by extrapolation of the evaporation rate curve, fitted in the vapour pressure regression curve. Under the study conditions, the vapour pressure of read across substance was found to be <1.5E-03 Pa at 20°C and <5.8E-03 Pa at 25°C (Brekelmans, 2012). Based on the results of the read across, a similar vapour pressure is expected for the test substance.

Description of key information

The vapour pressure was determined based on a study conducted with read across substance, C12 -16 ADBAC, using the isothermal thermo gravimetric effusion method according to OECD Guideline 104, EU Method A.4 and EPA OPPTS 830.7950 (Brekelmans, 2012). 

 

Key value for chemical safety assessment

Vapour pressure:

0.006 Pa

at the temperature of:

25 °C