Registration Dossier
Registration Dossier
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EC number: 219-397-9 | CAS number: 2431-50-7
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original data not available
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- !SIDSP*
- Year:
- 1 993
- Bibliographic source:
- OECD/SIDS. Screening Information Data Set (SIDS) of OECD High Production Volume Chemicals Programme, 19, (1993)
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- Principles of method if other than guideline:
- Developmental toxicity and teratogenicity were analyzed
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2,3,4-trichlorobut-1-ene
- EC Number:
- 219-397-9
- EC Name:
- 2,3,4-trichlorobut-1-ene
- Cas Number:
- 2431-50-7
- Molecular formula:
- C4H5Cl3
- IUPAC Name:
- 2,3,4-trichlorobut-1-ene
- Details on test material:
- - Name of test material (as cited in study report): 1-Butene, 2,3,4-trichloro
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Details on mating procedure:
- no data
- Duration of treatment / exposure:
- 6th to 16th day of gestation
- Frequency of treatment:
- 6h/d
- Duration of test:
- 10 d
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 0.0007, 0.003, 0.017 mg/L (0, 0.1, 0.5, 2.5 ppm)
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- yes
- Details on study design:
- Post observation period: until 21st day of gestation
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:yes
Details on maternal toxic effects:
At 2.5 ppm: decreased food consumption and bodyweights
Effect levels (maternal animals)
open allclose all
- Dose descriptor:
- NOAEC
- Effect level:
- 0.003 other: mg/L
- Basis for effect level:
- other: maternal toxicity
- Dose descriptor:
- LOAEC
- Effect level:
- 0.017 other: mg/L
- Basis for effect level:
- other: maternal toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no data
Details on embryotoxic / teratogenic effects:
At 2.5 ppm: decreased foetal weight, no teratogenicity
Effect levels (fetuses)
open allclose all
- Dose descriptor:
- NOAEC
- Effect level:
- 0.003 other: mg/L
- Basis for effect level:
- other: teratogenicity
- Dose descriptor:
- LOAEC
- Effect level:
- 0.017 other: mg/L
- Basis for effect level:
- other: fetotoxicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
Freetext:
NOEL for maternal animals: 0.5 ppm
NOEL for offspring: 0.5 ppm
Maternal general toxicity: decreased food consumption and
bodyweights in the 2.5 ppm-group
Pregnancy and litter data: decreased foetal weight in the
2.5 ppm-group, no teratogenicity
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
