Registration Dossier

Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
screening for reproductive / developmental toxicity
Type of information:
experimental study
Adequacy of study:
key study
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2011
Report Date:
2011

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
Deviations:
yes
Qualifier:
according to
Guideline:
other:
Deviations:
yes
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure (if applicable):
nose only

Results and discussion

Results: P0 (first parental animals)

Effect levels (P0)

open allclose all
Dose descriptor:
NOAEC
Effect level:
>= 297.3 mg/m³ air (analytical)
Based on:
test mat.
Sex:
male/female
Dose descriptor:
NOAEC
Effect level:
100.1 mg/m³ air (analytical)
Based on:
test mat.
Sex:
female
Basis for effect level:
other:

Results: F1 generation

Effect levels (F1)

Dose descriptor:
NOAEC
Generation:
F1
Effect level:
>= 297.3 mg/m³ air (analytical)
Based on:
test mat.
Sex:
male/female

Overall reproductive toxicity

Reproductive effects observed:
not specified

Applicant's summary and conclusion