Undec-10-enal

Long-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Justification for type of information:

Data is from computational model developed by USEPA

Qualifier:

according to guideline

Guideline:

other: Modelling database

Principles of method if other than guideline:

Long term toxicity effect of test chemical on freshwater daphnia magna were studied for 21 days.

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Daphnia sp.

Details on test organisms:

- Common name: Water flea

Test type:

flow-through

Water media type:

freshwater

Total exposure duration:

21 d

Reference substance (positive control):

not specified

Key result

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

0.201 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

not specified

Remarks on result:

other: Neutral Organic SAR

Validity criteria fulfilled:

no

Conclusions:

After the exposure of test chemical with daphnia for 21 days, no effcet were observed at 0.201 mg/l.

Executive summary:

Using the EPI Suite, the long term toxicity on aquatic invertebrate daphnia magna was predicted for test substance. On the basis of no effects observed in a freshwater system, the no observed effect concentration (NOEC) value for the substance is estimated to be 0.201 mg/l for aquatic invertebrate for 21 d duration. Based on this value, it can be concluded that the test chemical can be considered as toxic to fish at environmentally relevant concentrations and can be considered to be classified in aquatic chronic category 2.

Description of key information

Using the EPI Suite, the long term toxicity on aquatic invertebrate daphnia magna was predicted for test substance. On the basis of no effects observed in a freshwater system, the no observed effect concentration (NOEC) value for the substance is estimated to be 0.201 mg/l for fish for 21 d duration. Based on this value, it can be concluded that the test chemical can be considered as toxic to fish at environmentally relevant concentrations and can be considered to be classified in aquatic chronic category 2.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

0.201 mg/L

Additional information

Summarized result for the toxicity of test chemical and structually and functionally similar read across chemicals were reviewed and mention as below:

Using the EPI Suite, the long term toxicity on aquatic invertebrate daphnia magna was predicted for test substance. On the basis of no effects observed in a freshwater system, the no observed effect concentration (NOEC) value for the substance is estimated to be 0.201 mg/l for fish for 21 d duration. Based on this value, it can be concluded that the test chemical can be considered as toxic to fish at environmentally relevant concentrations and can be considered to be classified in aquatic chronic category 2.

Similarly in the second study from authoritative database long term toxicity of aquatic invertebrates was evaluated for 21days according OECD Guideline 211 (Daphnia magna Reproduction Test). DMF and HCO-40 were used in this test to prepare the test solution due to low water solubility. Three test concentrations were prepared at 0.30, 0.55 and 1.00 mg/L as nominal concentration. However, Since the measured concentrations in groups tested at 21 day were different over 20% from their corresponding nominal concentration, the concentrations were expressed by timeweighted as 0.24, 0.49 and 0.84 mg/L.The concentration of vehicles used was 40 mg/L in the final test solution which has no significant effect on reproduction as revealed by a vehicle only control and is less than the recommended concentration of vehicle, i.e. 100 mg/L). No significant difference on cumulative number of dead parental was observed among control, vehicle control and treated groups. NOEC (21d) and EC50 (21d) was observed to be >0.84 mg/l . The effect concentration were greater than the highest concentration used in the test because there was no statistical difference on cumulative number of juveniles produced per adult alive for 21 days.