Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 222-182-2 | CAS number: 3380-34-5
Solubility in organic solvents / fat solubility
Administrative data
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
- Principles of method if other than guideline:
- The solubility of Triclosan was determined by suspending an excess of the compound in the buffer and in the solvents n-hexane and n-octanol, andstirring the suspensions in a thermostatted water bath for 3 days. The concentration in the filtered solutions was then determined by HPLC analysis with a UV detector by the method of external calibration.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Triclosan
- EC Number:
- 222-182-2
- EC Name:
- Triclosan
- Cas Number:
- 3380-34-5
- Molecular formula:
- C12H7Cl3O2
- IUPAC Name:
- 5-chloro-2-(2,4-dichlorophenoxy)phenol
Constituent 1
- Specific details on test material used for the study:
- - Substance type: organic
- Physical state: solid
- Lot/batch No.: 08246CL7 and 08454CL7
Results and discussion
Solubility in organic solvents / fat solubilityopen allclose all
- Medium:
- other: n-hexane
- Solubility:
- 16.6 g/kg solvent
- Temp.:
- 10 °C
- Medium:
- other: n-hexane
- Solubility:
- 31.5 g/kg solvent
- Temp.:
- 20 °C
- Medium:
- other: n-hexane
- Solubility:
- 63.2 g/kg solvent
- Temp.:
- 30 °C
- Medium:
- n-octanol
- Solubility:
- 52.1 g/kg solvent
- Temp.:
- 10 °C
- Medium:
- n-octanol
- Solubility:
- 48.1 g/kg solvent
- Temp.:
- 20 °C
- Medium:
- n-octanol
- Solubility:
- 55.6 g/kg solvent
- Temp.:
- 30 °C
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
