Registration Dossier
Registration Dossier
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EC number: 278-780-9 | CAS number: 77881-13-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- Jan 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: only shortly reported non-GLP orientating study but basic data given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- only 3 instead of 5 animals per dose group used; application volume varying (up to 40 ml/kg)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 17 beta-cyano-17 alpha-hydroxy-4-androsten-3-on
- IUPAC Name:
- 17 beta-cyano-17 alpha-hydroxy-4-androsten-3-on
- Details on test material:
- - Name of test material (as cited in study report): ZK 74.804
- Batch No.: 4419050182
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: physiol. saline + Myrj 53
- Doses:
- 0, 0.25, 0.5, 1.0, 2.0, 3.5 and 5.0 g/kg (with an application volume of 40 ml/kg (vehicle control) and 2, 4, 8, 16, 28 or 40 ml/kg respectively)
- No. of animals per sex per dose:
- 3
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
No mortalities occurred. Moreover, no compound-related findings were observed in body weight gain or autopsy. Main clinical findings were spastic gait and ruffled fur which were observed on the first day after application in all dose groups. From day 2 onwards all animals were without findings.
Applicant's summary and conclusion
- Executive summary:
In an orientating toxicity study the single oral administration of the test substance (ZK 74.804) to male rats at doses of 0.25, 0.5, 1.0, 2.0, 3.5 and 5 g/kg was tolerated without any mortality or compound-related macroscopic pathological signs. Main clinical findings were spastic gait and ruffled fur which were observed on the first day after application in all dose groups. From day 2 onwards all animals were without findings.
The acute oral toxicity of AD-Cyanhydrin in rats is therefore above 5 g/kg body weight.
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