Registration Dossier
Registration Dossier
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EC number: 228-085-1 | CAS number: 6117-80-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic data given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 959
- Report date:
- 1959
Materials and methods
- Principles of method if other than guideline:
- Method: other: BASF-Test
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- But-2-ene-1,4-diol
- EC Number:
- 203-787-0
- EC Name:
- But-2-ene-1,4-diol
- Cas Number:
- 110-64-5
- Molecular formula:
- C4H8O2
- IUPAC Name:
- 2-Butene-1,4-diol
- Reference substance name:
- (Z)-2-butene-1,4-diol
- EC Number:
- 228-085-1
- EC Name:
- (Z)-2-butene-1,4-diol
- Cas Number:
- 6117-80-2
- Molecular formula:
- C4H8O2
- IUPAC Name:
- but-2-ene-1,4-diol
- Details on test material:
- - Name of test material (as cited in study report): Buten2-diol-1,4
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10 % - Doses:
- 1600, 800, 640, 400, 200 µl/kg
- No. of animals per sex per dose:
- 1600 and 200 µl/kg: 3 animals; 800, 640 µl/kg: 10 animals; 400 µl/kg:5 animals
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 856 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1600 µl/kg: animal died within 24 hours; 800 µl/kg: 6 animals died after 24 hours; 640 µl/kg: 2 animals died after 24 hours, 1 animal died after 48 hours
- Clinical signs:
- other: Depression, stagger, respiration disorder
- Gross pathology:
- NAD
Any other information on results incl. tables
Originally: LD50 ca. 0.8 ml/kg
| Dose µl/kg | number of dead animals | 1 hour | 24 hours | 48 hours | 7 days |
| 1600 | 3/3 | 0/3 | 3/3 | ||
| 800 | 6/10 | 0/10 | 6/10 | 6/10 | 6/10 |
| 640 | 3/10 | 0/10 | 2/10 | 3/10 | 3/10 |
| 400 | 0/5 | 0/5 | |||
| 200 | 0/3 | 0/3 | |||
| control animal | 0/20 |
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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