Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 251-118-6 | CAS number: 32588-76-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study consisted of an andequate number of animals adminstered a limit dose. The methodology is consistent with current guidelines. The study was performed prior to established guidelines and GLPs.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Section 1500.41 - Hazardous Substances and Articles, Administration and Envforcement Regulations, U.S. Federal Register, 38(187), p 27019, 27 Sept 1973.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 434 (Acute Dermal Toxicity - Fixed Dose Procedure)
- Principles of method if other than guideline:
- Test material applied to clipped back of rabbits, covered in place for 24 hr and observed for toxicity and mortality for 14 d.
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- N,N'-ethylenebis(3,4,5,6-tetrabromophthalimide)
- EC Number:
- 251-118-6
- EC Name:
- N,N'-ethylenebis(3,4,5,6-tetrabromophthalimide)
- Cas Number:
- 32588-76-4
- Molecular formula:
- C18H4Br8N2O4
- IUPAC Name:
- N,N'-ethylenebis(3,4,5,6-tetrabromophthalimide)
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino rabbits
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hr
- Doses:
- single dose of 2.0 gm/kg bw
- No. of animals per sex per dose:
- 6 rabbits total
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- > 2 other: gm/kg
- Based on:
- test mat.
- Mortality:
- no rabbits died on test
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- EBTBP was not acutely toxic when administered dermally to rabbits.
- Executive summary:
EBTBP was administered as a single dose of 2,000 mg/kg to the clipped skin of 6 albino rabbits. The skin of three of the animals was abraded prior to treatment. The test site was wrapped with an impervious material. The wrapping was removed at 24 hr, any excess test article removed, and the animals observed for 14 days. No animals died during the test. The dermal LD50 was > 2,000 mg/
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
