Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 251-118-6 | CAS number: 32588-76-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study consisted of an andequate number of animals adminstered a limit dose. The methodology is consistent with current guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- N,N'-ethylenebis(3,4,5,6-tetrabromophthalimide)
- EC Number:
- 251-118-6
- EC Name:
- N,N'-ethylenebis(3,4,5,6-tetrabromophthalimide)
- Cas Number:
- 32588-76-4
- Molecular formula:
- C18H4Br8N2O4
- IUPAC Name:
- N,N'-ethylenebis(3,4,5,6-tetrabromophthalimide)
- Details on test material:
- pale yellow powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- aerodynamic dyameter of particle size = 6.0 microns +- 2.22.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gravimetric
- Duration of exposure:
- 1 h
- Concentrations:
- 203 mg/L
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 203 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
Any other information on results incl. tables
No rats died on the study.
Dyspnea was observed during the exposure and continued post-exposure (up to 5 days) in a few animals. Mean body weight gain was normal 14 days after exposure. At necropsy, red foci in the lungs of a few rats were observed.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The 1 hr LC50 was > 203 mg/L.
- Executive summary:
One group of 5 male and 5 female albino rats was exposed to EBTBP at a concentration of 203 mg/L for 1 hour. Dyspnea and nasal discharge were the principal signs observed during the exposure. No deaths occurred during treatment or the during the 14 day observation period. The inhalation LC50 was > 203 mg/L for 1 hour. This study was performed according to Good Laboratory Practices.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
