Dihexadecyl peroxodicarbonate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1976

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study was performed pre-GLP and pre-guideline. The report is very concise. No data on test item composition or purity.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Remarks:

pre-GLP

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Dihexadecyl peroxodicarbonate

EC Number:

247-611-0

EC Name:

Dihexadecyl peroxodicarbonate

Cas Number:

26322-14-5

Molecular formula:

C34H66O6

IUPAC Name:

1-[({[(hexadecyloxy)carbonyl]peroxy}carbonyl)oxy]hexadecane

Details on test material:

White crystalline powder
Perkadox 24
di-cetyl peroxydicarbonate

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: CIVO-TNO
- Age at study initiation: Young
- Weight at study initiation: males 221 to 287 g and females 147 to 180 g
- Fasting period before study: overnight
- Housing: groups of five in screen-bottomed stainless steel cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 25
- Humidity (%): no data
- Air changes (per hr): no data, a well-ventilated room
- Photoperiod (hrs dark / hrs light): no data

IN-LIFE DATES: no data:

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: Shellsol T

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 50% (w/v) suspension
- Amount of vehicle (if gavage): 50%

MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg bw

Doses:

5000 mg/kg bw

No. of animals per sex per dose:

10

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: None
- Necropsy of survivors performed: yes
:

Statistics:

None

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

>= 5 000 mg/kg bw

Based on:

test mat.

Mortality:

No deaths occurred.

Clinical signs:

other: None of the rats showed any reaction upon the treatment. At the end of the observation period all treated animals looked quite healthy.

Gross pathology:

Macroscopic examination of the surviving rats revealed no treatment-related gross alterations.

Other findings:

No data.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

LD50 ≥ 5000 mg/kg bw

Executive summary:

10 male and 10 female were administered a 50 %{w/v} suspension of the test substance in Shellsol T.

None of the rats showed any reaction upon the treatment and no deaths occurred. At the end of the observation period all treated animals looked quite healthy. Macroscopic examination of the surviving rats revealed no treatment-related gross alterations

From the results it appeared that the LD50 is higher than 5 g/kg body weight.