Registration Dossier
Registration Dossier
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EC number: 203-702-7 | CAS number: 109-76-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1966
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data are given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Method: BASF-test
0.05 mL instead of 0.1 mL was used as dose level. - GLP compliance:
- no
Test material
- Reference substance name:
- Trimethylenediamine
- EC Number:
- 203-702-7
- EC Name:
- Trimethylenediamine
- Cas Number:
- 109-76-2
- Molecular formula:
- C3H10N2
- IUPAC Name:
- propane-1,3-diamine
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: adjacent eye
- Amount / concentration applied:
- 50 µL
- Observation period (in vivo):
- 1h, 24h, 8 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- The saline-treated (NaCl) adjacent eye served as control.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: corrosion
- Basis:
- mean
- Time point:
- other: 10 min, 1h, 24h
- Remarks on result:
- other: Corrosion of conjunctivae and whole eyeball; bloody secretion; eyelids: scabs
- Irritation parameter:
- other: corrosion
- Basis:
- mean
- Time point:
- other: 8 days
- Remarks on result:
- other: Eyelids closed by scabs; eyeball most likely destroyed
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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