Registration Dossier
Registration Dossier
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EC number: 201-244-2 | CAS number: 80-04-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 January 2011 to 01 June 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 1.9
- Temp.:
- 25 °C
- Remarks on result:
- other: No pH data.
- Type:
- log Pow
- Partition coefficient:
- 2.4
- Temp.:
- 25 °C
- Remarks on result:
- other: No pH data.
- Type:
- log Pow
- Partition coefficient:
- 2.5
- Temp.:
- 25 °C
- Remarks on result:
- other: No pH data.
- Type:
- log Pow
- Partition coefficient:
- 2.3
- Temp.:
- 25 °C
- Remarks on result:
- other: Log 10 Pow of mean of Pow values. No pH data.
- Details on results:
- Rikabinol HB chromatographed as three distinct components under these conditions and these were determined to have log10Pow values of 1.9, 2.4 and 2.5 (equivalent Pow values of 82, 220 and 290).
- Conclusions:
- The components of Rikabinol HB were found to have log10Pow values of 1.9, 2.4 and 2.5.
Reference
Description of key information
The components of Rikabinol HB were found to have log10Pow values of 1.9, 2.4 and 2.5.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.5
- at the temperature of:
- 25 °C
Additional information
The determination of partition coefficient of HBPA was carried out using the HPLC method (Huntingdon Life Sciences, 2012, Study MOG0004). The procedure was designed to be compatible with the EC Method A.8 and the OECD test guideline 117, and was conducted in compliance with GLP.
The components of HBPA were determined to have log10Pow values of 1.9, 2.4 and 2.5 (equivalent Pow values of 82, 220 and 290).
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
