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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2000-04-05 to 2000-12-11
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. Purity is specified, and isomers composition is available from the notifier. However, some information are unclear. Therefore validation applies with restrictions.
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
GLP compliance:
yes
Remarks:
(no certificate)
Type of method:
gas saturation method
Specific details on test material used for the study:
Storage condition of test material: at room temperature, protected from light, under nitrogen.
Key result
Temp.:
20 °C
Vapour pressure:
0.053 Pa
Remarks on result:
other: +/- 0.008 Pa

The vapour pressure of the test item was measured at each temperature; the results are shown in the table below:

Temp. (°C) 1/T (K) area (mU.A) desorption vol. (mL) vaporate in V (mg/mL) mass vaporated (mg) V. of gas saturated (L) Temp. meter (°C) Vapour pressure (Pa) Log P
19.3 0.0034 8.750 1 0.261 0.261 43.2 24.9 0.054 -1.268
19.3 0.0034 7.523 1 0.216 0.216 38.3 24.8 0.051 -1.292
19.3 0.0034 19.737 1 0.529 0.529 92.7 24.9 0.051 -1.292
39.5 0.0032 9.246 1 0.264 0.264 21.9 25.7 0.1159 -0.936
38.7 0.0032 7.889 1 0.230 0.230 19.3 26.0 0.1144 -0.942
38.8 0.0032 4.645 1 0.130 0.130 10.4 26.2 0.1201 -0.921

The regression equation log P (Pa) as a function of 1/T is:

log (P) = -1621.4 / T + 4.2616

and the coefficient R2 obtained is 0.995

The interpolated vapour pressure at 20°C is 0.053 +/- 0.008 Pa.

The current error on the result is +/-16%, taking into account all possible errors in the measurement: volume of gas passed through; temperature of the enclosure, gas in the meter, efficiency of trapping and chemical desorption of the substance determined by the HPLC method.

Conclusions:
Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), << 500 Pa).
Executive summary:

The vapour pressure of the test substance was measured under GLP according to EU A4 guideline, gas saturation method.

Three measurements were performed for each temperature at ca 20 and 40°C. The slope and intercept of the linear relashionship between log VP and 1/T was calculated, and the vapour pressure at 20°C was interpolated from this equation.

The vapour pressure of the test substance is ca 0.053 Pa at 20°C.

Description of key information

Low volatility.

Key value for chemical safety assessment

Vapour pressure:
0.053 Pa
at the temperature of:
20 °C

Additional information

A reliable experimental study, conducted according to a recognized EC method and under GLP, is available. Despite restrictions due to missing information in the report, it is considered as a key study. Measurements were performed at ca 19 and 39°C, and the interpolated result at 20°C is retained as key value for purpose of CSA.

It should be noted that, due to the multi-isomers nature of the substance, this result may refer to the most volatile one; however, as a single boiling point was observed, vapour pressure is not anticipated to vary significantly between components.