Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1949
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data from publication containing range finding results

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1949

Materials and methods

Principles of method if other than guideline:
For details not reported in this publication see previous publication in Am. J. Ophthalmol. 29, 1363-1372 (1946).
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test substance: 3,3,5-Trimethylcyclohexanol, no further data

Test animals

Species:
rabbit

Test system

Type of coverage:
open
Vehicle:
other: initially none; acetone for dilution series of corrosive substances
Amount / concentration applied:
undiluted total volume applied : 0.01 ml
Duration of treatment / exposure:
24 hour(s)
Observation period:
24 hours after exposure
Number of animals:
5

Results and discussion

Any other information on results incl. tables

Irritation index: 5 (= strong erythema, edema, or slight necrosis)

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information
Conclusions:
In a range finding studies with rabbits the skin irritation was determined at a scaling of 5 out of 10. The study is used as key study.