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Administrative data

Description of key information

Skin irritation/corrosion:  irritating(Read-across).
Eye irritation: irritating (Read-across).
Respiratory irritation: this information is not available.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1949
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data from publication containing range finding results
Principles of method if other than guideline:
For details not reported in this publication see previous publication in Am. J. Ophthalmol. 29, 1363-1372 (1946).
GLP compliance:
no
Species:
rabbit
Type of coverage:
open
Vehicle:
other: initially none; acetone for dilution series of corrosive substances
Amount / concentration applied:
undiluted total volume applied : 0.01 ml
Duration of treatment / exposure:
24 hour(s)
Observation period:
24 hours after exposure
Number of animals:
5

Irritation index: 5 (= strong erythema, edema, or slight necrosis)

Interpretation of results:
irritating
Remarks:
Migrated information
Conclusions:
In a range finding studies with rabbits the skin irritation was determined at a scaling of 5 out of 10. The study is used as key study.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1949
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data from publication containing range finding results
Principles of method if other than guideline:
For details not reported in this publication see previous publications in J. Ind. Hyg. Toxicol. 26, 269-273 (1944) and J. Ind. Hyg. Toxicol. 30, 63-68 (1948).
GLP compliance:
no
Species:
rabbit
Amount / concentration applied:
undiluted
Duration of treatment / exposure:
24 hour(s)
Number of animals or in vitro replicates:
5
Details on study design:
Comment: not rinsed

Grade 9

Interpretation of results:
irritating
Remarks:
Migrated information
Conclusions:
The eye irritation was rated 9 out of 20 points in a study with albino rabbits. A score of >5 was indicated as severe injury
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Applying a worst case approach and using the study with the most severe result, the substance is hereby classified as eye and skin irritant.


Justification for selection of skin irritation / corrosion endpoint:
No skin irritation study on the substance 2,3,6-Trimethylcyclohexanol itself was available.
Therefore, a read-across from 3,3,5-Trimethylcyclohexanol was performed to address this endpoint, based on chemical structure similarity. In a range finding study with rabbits the skin irritation was determined at a scaling of 5 out of 10, indicating a skin irritant potential (publication Smyth H.F. ; Carpenter C.P.; Weil C.S., 1949).

Justification for selection of eye irritation endpoint:
No eye irritation study on the substance 2,3,6-Trimethylcyclohexanol itself was available.
Therefore, a read-across from 3,3,5-Trimethylcyclohexanol was performed to address this endpoint, based on chemical structure similarity. The eye irritation was rated 9 out of 20 points in a study with albino rabbits. A score of >5 was indicated as severe injury (publication Smyth H.F. ; Carpenter C.P.; Weil C.S., 1949).

Effects on skin irritation/corrosion: irritating

Effects on eye irritation: irritating

Justification for classification or non-classification