Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1949
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data from handbook or collection of data, important study details and confidence interval given, considered reliable.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1949

Materials and methods

Principles of method if other than guideline:
Method: other: For details not reported in this publication see previous publications in J. Ind. Hyg. Toxicol. 26, 269-273 (1944) and J. Ind. Hyg. Toxicol. 30, 63-68 (1948).
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test substance: 3,3,5-Trimethylcyclohexanol, no further data

Test animals

Species:
rabbit

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: none (i.e. undiluted test substance)
Doses:
four dosages in a geometrical series
No. of animals per sex per dose:
5

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
2 430 mg/kg bw

Any other information on results incl. tables

RS-Freetext:
LD50 reported as 2.8 ml/kg bw

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Remarks:
Migrated information
Conclusions:
A dermal study on 3,3,5-Trimethylcyclohexanol with rabbits applying the test substance in four doses yields a LD50 reported as 2.8 ml/kg bw.