Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1949
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data from handbook or collection of data, important study details and confidence interval given, considered reliable.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1949

Materials and methods

Principles of method if other than guideline:
Method: other: For details not reported in this publication see previous publications in J. Ind. Hyg. Toxicol. 26, 269-273 (1944) and J. Ind. Hyg. Toxicol. 30, 63-68 (1948).
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test substance: 3,3,5-Trimethylcyclohexanol, no further data

Test animals

Species:
rat
Strain:
Sherman
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
four dosages in a geometrical series
No. of animals per sex per dose:
5

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
3 250 mg/kg bw

Any other information on results incl. tables

RS-Freetext:
Confidence interval ("fiducial range"): 2740 - 3860 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Remarks:
Migrated information
Conclusions:
An acute oral toxicity LD50 for male rats of 3250 mg/kg (CI 2740 - 3860 mg/kg bw) for 3,3,5-Trimethylcyclohexanol was obtained in a published study from 1949. The study is taken as key study for the asssessment of 2,3,6-Trimethycyclohexanol.